1 microRNAs 15 a and 16 regulate tumor proliferation in Multiple Myeloma
نویسندگان
چکیده
1 Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 2 Unit of Blood Diseases and Cell Therapies, University of Brescia Medical School, Brescia, Italy 3 Dept. of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy 4 Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 5 Dept. of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy 6 Dept. of Hematology, Mayo Clinic, Rochester, MN
منابع مشابه
MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.
Detailed genomic studies have shown that cytogenetic abnormalities contribute to multiple myeloma (MM) pathogenesis and disease progression. Nevertheless, little is known about the characteristics of MM at the epigenetic level and specifically how microRNAs regulate MM progression in the context of the bone marrow milieu. Therefore, we performed microRNA expression profiling of bone marrow deri...
متن کاملLYMPHOID NEOPLASIA MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
1Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; 2Unit of Blood Diseases and Cell Therapies, University of Brescia Medical School, Brescia, Italy; 3Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy; 4Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Bo...
متن کاملFrequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...
متن کاملMicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulate in the bone marrow, where a complex microenvironment made by different cell types supports proliferation, survival, and drug resistance of tumor cells. MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at posttranscriptional level. Emerging evidence indicates that miRNAs are...
متن کاملMiR-6165 Dysregulation in Breast Cancer and Its Effect on Cell Proliferation and Migration
Background: ncRNAs have been identified as oncogenic drivers and tumor suppressors in any type of cancer. Although many classes of ncRNAs have been reported, most studies have been performed on microRNAs (miRNAs). miRNAs can regulate several target genes and affect important processes such as homeostasis, angiogenesis, cell proliferation, differentiation, and apoptosis. Located in the p75NTR ge...
متن کامل